Continuous Cefazolin Iv 6g in 560 Mililiters Ns
| Parenteral Adult: Mild: 0.25-0.5 g 8 hrly. Moderate to severe: 0.5-1 g 6-8 hrly. Severe, life-threatening: 1-1.5 g 6 hrly. Max: 12 g daily. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Parenteral Adult: 1 g 12 hrly to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 12 g daily. Parenteral Adult: 500 mg 12 hrly to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. Max: 12 g daily. Parenteral Adult: 1 g given 30-60 min prior to surgery, followed by 0.5-1 g during surgery for lengthy procedures, then 0.5-1 g 6-8 hrly after surgery for 24 hr or up to 5 days. All doses to be given by deep IM inj, slow IV inj over 3-5 min, or intermittent or continuous IV infusion. | ||||||||
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| Add 2 or 2.5 mL of sterile water for inj to the vial labelled as 500 mg or 1 g, respectively, to provide soln containing approx 225 or 330 mg/mL. Further dilute in approx 5 mL of sterile water for inj to be used for IV inj or in 50-100 mL of compatible IV soln for IV infusion. | ||||||||
| Aminoglycosides. Y-site: Amphotericin B cholesteryl sulfate complex, caspofungin, idarubicin, pemetrexed, pentamidine, vinorelbine. Variable: Amiodarone, anakinra, cisatracurium, doxapram, hetastarch in NS, hydromorphone, pantoprazole, promethazine, vancomycin. | ||||||||
| Hypersensitivity to cephalosporins. | ||||||||
| Patient w/ history of hypersensitivity to penicillins, GI disease particularly colitis, seizure disorder. Renal impairment. Pregnancy and lactation. | ||||||||
| Diarrhoea, oral candidiasis, vomiting, nausea, stomach cramps, anorexia; eosinophilia, itching, drug fever, skin rash, Stevens-Johnson syndrome; neutropenia, leucopenia, thrombocytopenia, thrombocythemia; transient elevation in SGOT, SGPT and alkaline phosphatase levels; hepatitis; increased BUN and creatinine levels, renal failure; phlebitis, induration; genital and anal pruritus (e.g. vulvar pruritus, genital moniliasis, vaginitis). | ||||||||
| IM/Intraocular/Intraperitoneal/IV/Parenteral: B | ||||||||
| Monitor prothrombin time; renal, hepatic and haematological function; monitor for signs of anaphylaxis during 1st dose. | ||||||||
| May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine. May decrease the protein binding of fosphenytoin and phenytoin. Probenecid may decrease renal tubular secretion of cefazolin, resulting in increased and prolonged blood levels. May increase the nephrotoxic effects of aminoglycosides. | ||||||||
| Disulfiram-like reaction w/ alcohol. | ||||||||
| False-positive reaction in urinary glucose test using Benedict's soln, Fehling's soln or Clinitest tablets. Positive direct and indirect Coombs test. | ||||||||
| Description: Cefazolin binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. | ||||||||
 Source: National Center for Biotechnology Information. PubChem Database. Cefazolin, CID=33255, https://pubchem.ncbi.nlm.nih.gov/compound/Cefazolin (accessed on Jan. 21, 2020) | ||||||||
| Store between 20-25°C. Protect from light. Reconstituted soln/premixed inj: Store at or below -20°C. | ||||||||
| Cephalosporins | ||||||||
| Anon. Cefazolin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/10/2014. Buckingham R (ed). Cefazolin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/10/2014. Cefazolin Sodium Injection, Solution (Baxter Healthcare Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 09/10/2014. McEvoy GK, Snow EK, Miller J et al (eds). Cefazolin Sodium. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 09/10/2014. Preston CL (ed). Cefazolin Drug Interactions. Stockley's Drug Interactions [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/10/2014. |
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